4F7N

Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea)

Summary for 4F7N

Related4F6S 4F6U 4F6W 4F70 4F7J 4F7L
DescriptorCyclin-dependent kinase 8, Cyclin-C, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea, ... (5 entities in total)
Functional Keywordsprotein kinase complex, proteros, transferase-transcription-inhibitor complex, transferase/transcription/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P49336 P24863
Total number of polymer chains2
Total molecular weight81183.54
Authors
Schneider, E.V.,Boettcher, J.,Huber, R.,Maskos, K. (deposition date: 2012-05-16, release date: 2013-05-01, Last modification date: 2015-04-01)
Primary citation
Schneider, E.V.,Bottcher, J.,Huber, R.,Maskos, K.,Neumann, L.
Structure-kinetic relationship study of CDK8/CycC specific compounds.
Proc.Natl.Acad.Sci.USA, 110:8081-8086, 2013
PubMed: 23630251 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1305378110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236000.4%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report