5BJT

Crystal structure of human FcRn with a peptide inhibitor at multiple sites

Summary for 5BJT

• Entry DOI: 10.2210/pdb5bjt/pdb
• Related: 3M17 3M1B
• Descriptor: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, peptide inhibitor (3 entities in total)
• Functional Keywords: immunoglobulin binding protein, cell membrane, disulfide bond, glycoprotein, igg-binding protein, immunoglobulin domain, receptor, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immune response, mhc i, pyrrolidone carboxylic acid, secreted, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P55899; Secreted . Note=(Microbial infection) In the presence of M: P61769
• Total number of polymer chains: 15
• Total formula weight: 180983.55

Authors

Nienaber, V.,Badger, J. (deposition date: 2016-10-23, release date: 2017-03-22, Last modification date: 2023-09-27)

• Primary citation: Pyzik, M.,Rath, T.,Kuo, T.T.,Win, S.,Baker, K.,Hubbard, J.J.,Grenha, R.,Gandhi, A.,Kramer, T.D.,Mezo, A.R.,Taylor, Z.S.,McDonnell, K.,Nienaber, V.,Andersen, J.T.,Mizoguchi, A.,Blumberg, L.,Purohit, S.,Jones, S.D.,Christianson, G.,Lencer, W.I.,Sandlie, I.,Kaplowitz, N.,Roopenian, D.C.,Blumberg, R.S.; Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.; Proc. Natl. Acad. Sci. U.S.A., 114:E2862-E2871, 2017; PubMed: 28330995; DOI: 10.1073/pnas.1618291114

Experimental method

X-RAY DIFFRACTION (3.2 Å)