5BJT
Crystal structure of human FcRn with a peptide inhibitor at multiple sites
Summary for 5BJT
Entry DOI | 10.2210/pdb5bjt/pdb |
Related | 3M17 3M1B |
Descriptor | IgG receptor FcRn large subunit p51, Beta-2-microglobulin, peptide inhibitor (3 entities in total) |
Functional Keywords | immunoglobulin binding protein, cell membrane, disulfide bond, glycoprotein, igg-binding protein, immunoglobulin domain, receptor, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immune response, mhc i, pyrrolidone carboxylic acid, secreted, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P55899 Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 15 |
Total formula weight | 180983.55 |
Authors | Nienaber, V.,Badger, J. (deposition date: 2016-10-23, release date: 2017-03-22, Last modification date: 2023-09-27) |
Primary citation | Pyzik, M.,Rath, T.,Kuo, T.T.,Win, S.,Baker, K.,Hubbard, J.J.,Grenha, R.,Gandhi, A.,Kramer, T.D.,Mezo, A.R.,Taylor, Z.S.,McDonnell, K.,Nienaber, V.,Andersen, J.T.,Mizoguchi, A.,Blumberg, L.,Purohit, S.,Jones, S.D.,Christianson, G.,Lencer, W.I.,Sandlie, I.,Kaplowitz, N.,Roopenian, D.C.,Blumberg, R.S. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc. Natl. Acad. Sci. U.S.A., 114:E2862-E2871, 2017 Cited by PubMed: 28330995DOI: 10.1073/pnas.1618291114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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