3M17

Crystal structure of human FcRn with a monomeric peptide inhibitor

Summary for 3M17

Related3M1B
Related PRD IDPRD_001091
DescriptorIgG receptor FcRn large subunit p51, Beta-2-microglobulin, monomeric peptide inhibitor, ... (4 entities in total)
Functional Keywordsimmunoglobulin binding protein, cell membrane, disulfide bond, glycoprotein, igg-binding protein, immunoglobulin domain, membrane, receptor, transmembrane, amyloid, amyloidosis, disease mutation, glycation, immune response, mhc i, pyrrolidone carboxylic acid, secreted, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Single-pass type I membrane protein (By similarity) P55899
Secreted P61769
Total number of polymer chains12
Total molecular weight172033.55
Authors
Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V. (deposition date: 2010-03-04, release date: 2010-06-16, Last modification date: 2012-12-12)
Primary citation
Mezo, A.R.,Sridhar, V.,Badger, J.,Sakorafas, P.,Nienaber, V.
X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.
J.Biol.Chem., 285:27694-27701, 2010
PubMed: 20592032 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.120667
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.32240.7%5.5%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3m17
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Molmil generated image of 3m17
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Molmil generated image of 3m17
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More Biological unit images

Molmil generated image of 3m17
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Molmil generated image of 3m17
rotated about x axis by 90°
Molmil generated image of 3m17
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3m17.pdb12.gz [7.04 KB])
Coordinate files for Biological unit (3m17.pdb6.gz [21.51 KB])
Coordinate files for Biological unit (3m17.pdb11.gz [7.03 KB])
Coordinate files for Biological unit (3m17.pdb9.gz [7.11 KB])
Coordinate files for Biological unit (3m17.pdb7.gz [43.56 KB])
Coordinate files for Biological unit (3m17.pdb5.gz [43.54 KB])
Coordinate files for Biological unit (3m17.pdb2.gz [21.25 KB])
Coordinate files for Biological unit (3m17.pdb1.gz [43.81 KB])
Coordinate files for Biological unit (3m17.pdb8.gz [20.96 KB])
Coordinate files for Biological unit (3m17.pdb10.gz [7.11 KB])
Coordinate files for Biological unit (3m17.pdb3.gz [44.21 KB])
Coordinate files for Biological unit (3m17.pdb4.gz [21.66 KB])