5B7V

Human FGFR1 kinase in complex with CH5183284

「3WJ6」から置き換えられました

5B7V の概要

• エントリーDOI: 10.2210/pdb5b7v/pdb
• 分子名称: Fibroblast growth factor receptor 1, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: protein kinase, atp-binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71426.05

構造登録者

Fukami, T.A.,Lukacs, C.M.,Janson, C. (登録日: 2016-06-09, 公開日: 2016-06-22, 最終更新日: 2023-11-08)

• 主引用文献: Nakanishi, Y.,Akiyama, N.,Tsukaguchi, T.,Fujii, T.,Sakata, K.,Sase, H.,Isobe, T.,Morikami, K.,Shindoh, H.,Mio, T.,Ebiike, H.,Taka, N.,Aoki, Y.,Ishii, N.; The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor; Mol.Cancer Ther., 13:2547-2558, 2014; PubMed: 25169980; DOI: 10.1158/1535-7163.MCT-14-0248

実験手法

X-RAY DIFFRACTION (2.15 Å)