5B4L
Crystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Summary for 5B4L
Entry DOI | 10.2210/pdb5b4l/pdb |
Related | 5B4K |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 78945.72 |
Authors | |
Primary citation | Yoshikawa, M.,Hitaka, T.,Hasui, T.,Fushimi, M.,Kunitomo, J.,Kokubo, H.,Oki, H.,Nakashima, K.,Taniguchi, T. Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket Bioorg.Med.Chem., 24:3447-3455, 2016 Cited by PubMed: 27301679DOI: 10.1016/j.bmc.2016.05.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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