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5B4L

Crystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue MG A 1001
ChainResidue
AASP554
AGLU582
AHOH1101
AHOH1114
AHOH1118
AHOH1120
AHOH1135

site_idAC2
Number of Residues6
Detailsbinding site for residue ZN A 1002
ChainResidue
AASP554
AASP664
AHOH1104
AHOH1120
AHIS519
AHIS553

site_idAC3
Number of Residues14
Detailsbinding site for residue 6DW A 1003
ChainResidue
ATYR514
AHIS515
ALEU625
ATYR683
APHE686
APRO702
AMET703
ALYS708
AGLU711
AGLY715
AGLN716
APHE719
AHOH1111
AHOH1125

site_idAC4
Number of Residues7
Detailsbinding site for residue MG B 1001
ChainResidue
BASP554
BGLU582
BHOH1102
BHOH1104
BHOH1113
BHOH1121
BHOH1131

site_idAC5
Number of Residues6
Detailsbinding site for residue ZN B 1002
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BHOH1106
BHOH1121

site_idAC6
Number of Residues18
Detailsbinding site for residue 6DW B 1003
ChainResidue
ALYS695
ALEU696
BTYR514
BHIS515
BLEU625
BLEU665
BILE682
BTYR683
BPHE686
BPRO702
BMET703
BLYS708
BGLU711
BVAL712
BGLY715
BGLN716
BPHE719
BHOH1107

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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