5B25
Crystal structure of human PDE1B with inhibitor 3
Summary for 5B25
Entry DOI | 10.2210/pdb5b25/pdb |
Descriptor | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q01064 |
Total number of polymer chains | 4 |
Total formula weight | 158383.14 |
Authors | Ida, K.,Lane, W.,Snell, G.,Sogabe, S. (deposition date: 2016-01-07, release date: 2016-02-03, Last modification date: 2023-11-08) |
Primary citation | Li, P.,Zheng, H.,Zhao, J.,Zhang, L.,Yao, W.,Zhu, H.,Beard, J.D.,Ida, K.,Lane, W.,Snell, G.,Sogabe, S.,Heyser, C.J.,Snyder, G.L.,Hendrick, J.P.,Vanover, K.E.,Davis, R.E.,Wennogle, L.P. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases J.Med.Chem., 59:1149-1164, 2016 Cited by PubMed: 26789933DOI: 10.1021/acs.jmedchem.5b01751 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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