5AZ2

Crystal structure of the Fab fragment of 9E5, a murine monoclonal antibody specific for human epiregulin

5AZ2 の概要

• エントリーDOI: 10.2210/pdb5az2/pdb
• 分子名称: anti-human epiregulin antibody 9E5 Fab heavy chain, anti-human epiregulin antibody 9E5 Fab light chain (3 entities in total)
• 機能のキーワード: antibody, immunoglobulin, monoclonal antibody, epidermal growth factor, immune system
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47294.72

構造登録者

Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T. (登録日: 2015-09-16, 公開日: 2015-12-09, 最終更新日: 2020-02-26)

• 主引用文献: Kado, Y.,Mizohata, E.,Nagatoishi, S.,Iijima, M.,Shinoda, K.,Miyafusa, T.,Nakayama, T.,Yoshizumi, T.,Sugiyama, A.,Kawamura, T.,Lee, Y.H.,Matsumura, H.,Doi, H.,Fujitani, H.,Kodama, T.,Shibasaki, Y.,Tsumoto, K.,Inoue, T.; Epiregulin Recognition Mechanisms by Anti-epiregulin Antibody 9E5: STRUCTURAL, FUNCTIONAL, AND MOLECULAR DYNAMICS SIMULATION ANALYSES; J.Biol.Chem., 291:2319-2330, 2016; PubMed: 26627827; DOI: 10.1074/jbc.M115.656009

実験手法

X-RAY DIFFRACTION (1.603 Å)