5AYF

Crystal structure of SET7/9 in complex with cyproheptadine

Summary for 5AYF

Entry DOI	10.2210/pdb5ayf/pdb
Descriptor	Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine, ... (5 entities in total)
Functional Keywords	set domain, methyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29672.19
Authors	Niwa, H.,Handa, N.,Takemoto, Y.,Ito, A.,Tomabechi, Y.,Umehara, T.,Shirouzu, M.,Yoshida, M.,Yokoyama, S. (deposition date: 2015-08-20, release date: 2016-04-27, Last modification date: 2023-11-08)
Primary citation	Takemoto, Y.,Ito, A.,Niwa, H.,Okamura, M.,Fujiwara, T.,Hirano, T.,Handa, N.,Umehara, T.,Sonoda, T.,Ogawa, K.,Tariq, M.,Nishino, N.,Dan, S.,Kagechika, H.,Yamori, T.,Yokoyama, S.,Yoshida, M. Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription J.Med.Chem., 59:3650-3660, 2016 Cited by PubMed: 27088648 DOI: 10.1021/acs.jmedchem.5b01732 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.005 Å)

Structure validation