5AYF
Crystal structure of SET7/9 in complex with cyproheptadine
Summary for 5AYF
Entry DOI | 10.2210/pdb5ayf/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine, ... (5 entities in total) |
Functional Keywords | set domain, methyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29672.19 |
Authors | Niwa, H.,Handa, N.,Takemoto, Y.,Ito, A.,Tomabechi, Y.,Umehara, T.,Shirouzu, M.,Yoshida, M.,Yokoyama, S. (deposition date: 2015-08-20, release date: 2016-04-27, Last modification date: 2023-11-08) |
Primary citation | Takemoto, Y.,Ito, A.,Niwa, H.,Okamura, M.,Fujiwara, T.,Hirano, T.,Handa, N.,Umehara, T.,Sonoda, T.,Ogawa, K.,Tariq, M.,Nishino, N.,Dan, S.,Kagechika, H.,Yamori, T.,Yokoyama, S.,Yoshida, M. Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription J.Med.Chem., 59:3650-3660, 2016 Cited by PubMed: 27088648DOI: 10.1021/acs.jmedchem.5b01732 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.005 Å) |
Structure validation
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