5AYF

Crystal structure of SET7/9 in complex with cyproheptadine

5AYF の概要

• エントリーDOI: 10.2210/pdb5ayf/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine, ... (5 entities in total)
• 機能のキーワード: set domain, methyltransferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29672.19

構造登録者

Niwa, H.,Handa, N.,Takemoto, Y.,Ito, A.,Tomabechi, Y.,Umehara, T.,Shirouzu, M.,Yoshida, M.,Yokoyama, S. (登録日: 2015-08-20, 公開日: 2016-04-27, 最終更新日: 2023-11-08)

• 主引用文献: Takemoto, Y.,Ito, A.,Niwa, H.,Okamura, M.,Fujiwara, T.,Hirano, T.,Handa, N.,Umehara, T.,Sonoda, T.,Ogawa, K.,Tariq, M.,Nishino, N.,Dan, S.,Kagechika, H.,Yamori, T.,Yokoyama, S.,Yoshida, M.; Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription; J.Med.Chem., 59:3650-3660, 2016; PubMed: 27088648; DOI: 10.1021/acs.jmedchem.5b01732

実験手法

X-RAY DIFFRACTION (2.005 Å)