5AXP
Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
Summary for 5AXP
Entry DOI | 10.2210/pdb5axp/pdb |
Related | 2WYL 2WYM 3WYK |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, MAGNESIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 78853.44 |
Authors | |
Primary citation | Yoshikawa, M.,Kamisaki, H.,Kunitomo, J.,Oki, H.,Kokubo, H.,Suzuki, A.,Ikemoto, T.,Nakashima, K.,Kamiguchi, N.,Harada, A.,Kimura, H.,Taniguchi, T. Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor Bioorg.Med.Chem., 23:7138-7149, 2015 Cited by PubMed: 26494583DOI: 10.1016/j.bmc.2015.10.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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