5AWL

CRYSTAL STRUCTURE OF A MUTANT OF CHIGNOLIN, CLN025

Summary for 5AWL

Entry DOI	10.2210/pdb5awl/pdb
Related	1UAO 2RVD
Descriptor	A mutant of Chignolin, CLN025 (2 entities in total)
Functional Keywords	de novo protein, beta-hairpin, mini-protein, miniature protein
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	1294.32
Authors	Akiba, T.,Ishimura, M.,Odahara, T.,Harata, K.,Honda, S. (deposition date: 2015-07-05, release date: 2015-08-12, Last modification date: 2024-03-20)
Primary citation	Honda, S.,Akiba, T.,Kato, Y.S.,Sawada, Y.,Sekijima, M.,Ishimura, M.,Ooishi, A.,Watanabe, H.,Odahara, T.,Harata, K. Crystal structure of a ten-amino acid protein J.Am.Chem.Soc., 130:15327-15331, 2008 Cited by PubMed Abstract: What is the smallest protein? This is actually not such a simple question to answer, because there is no established consensus among scientists as to the definition of a protein. We describe here a designed molecule consisting of only 10 amino acids. Despite its small size, its essential characteristics, revealed by its crystal structure, solution structure, thermal stability, free energy surface, and folding pathway network, are consistent with the properties of natural proteins. The existence of this kind of molecule deepens our understanding of proteins and impels us to define an "ideal protein" without inquiring whether the molecule actually occurs in nature. PubMed: 18950166 DOI: 10.1021/ja8030533 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.11 Å)

Structure validation