5AWC

Crystal structure of human TLR8 in complex with MB-564

5AWC の概要

• エントリーDOI: 10.2210/pdb5awc/pdb
• 関連するPDBエントリー: 5AWA 5AWB 5AWD
• 分子名称: Toll-like receptor 8, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: immune system, tlr8, adjuvant, vaccine adjuvants, linnate immunity, glycosylation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 380863.99

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2015-07-03, 公開日: 2016-07-20, 最終更新日: 2020-07-29)

• 主引用文献: Beesu, M.,Caruso, G.,Salyer, A.C.D.,Khetani, K.K.,Sil, D.,Weerasinghe, M.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.; Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity; To Be Published,

実験手法

X-RAY DIFFRACTION (2.5 Å)