Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 8.5 min

Summary for 5AVV

Related5AVQ 5AVR 5AVS 5AVT 5AVU 5AVW 5AVX 5AVY 5AVZ 5AW0 5AW1 5AW2 5AW3 5AW4 5AW5 5AW6 5AW7 5AW8 5AW9
DescriptorNa, K-ATPase alpha subunit, Na+,K+-ATPase beta subunit, Phospholemman-like protein, ... (10 entities in total)
Functional Keywordsmembrane protein, ion pump, atpase, k+ binding, haloacid dehydrogenease superfamily, phosphate analogue, atp-binding, hydrolase, ion transport, nucleotide-binding, phosphoprotein, hydrolase-transport protein complex, kinetics, hydrolase/transport protein
Biological sourceSqualus acanthias (Spiny dogfish)
Cellular locationMembrane ; Single-pass type II membrane protein  C4IX13
Total number of polymer chains3
Total molecular weight158538.59
Ogawa, H.,Cornelius, F.,Hirata, A.,Toyoshima, C. (deposition date: 2015-07-01, release date: 2015-09-02)
Primary citation
Ogawa, H.,Cornelius, F.,Hirata, A.,Toyoshima, C.
Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
Nat Commun, 6:8004-8004, 2015
PubMed: 26258479 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms9004
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27980.7%4.9%10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report