5AVL
Crystal structure of LXRalpha in complex with tert-butyl benzoate analog, compound 32b
Summary for 5AVL
Entry DOI | 10.2210/pdb5avl/pdb |
Related | 5avi |
Descriptor | Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 2-[4-[4-[[2-[(2-methylpropan-2-yl)oxycarbonyl]-3-oxidanyl-4-(trifluoromethyl)phenyl]methoxy]phenyl]phenyl]ethanoic acid, ... (4 entities in total) |
Functional Keywords | agonist, complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q13133 Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 36175.03 |
Authors | Matsui, Y.,Hanzawa, H.,Tamaki, K. (deposition date: 2015-06-17, release date: 2015-08-26, Last modification date: 2023-11-08) |
Primary citation | Matsui, Y.,Yamaguchi, T.,Yamazaki, T.,Yoshida, M.,Arai, M.,Terasaka, N.,Honzumi, S.,Wakabayashi, K.,Hayashi, S.,Nakai, D.,Hanzawa, H.,Tamaki, K. Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists Bioorg.Med.Chem.Lett., 25:3914-3920, 2015 Cited by PubMed: 26238323DOI: 10.1016/J.BMCL.2015.07.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report