5AR8

RIP2 Kinase Catalytic Domain (1 - 310) complex with Biphenylsulfonamide

5AR8 の概要

• エントリーDOI: 10.2210/pdb5ar8/pdb
• 関連するPDBエントリー: 5AR2 5AR3 5AR4 5AR5 5AR7
• 分子名称: RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, 2,6-bis(fluoranyl)-N-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide (3 entities in total)
• 機能のキーワード: transferase, kinase domain, kinase inhibitor, structure-based drug design, inhibitor selectivity
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm : O43353
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76581.47

構造登録者

Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. (登録日: 2015-09-24, 公開日: 2015-10-21, 最終更新日: 2024-01-10)

• 主引用文献: Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Ouellette, M.,Totoritis, R.,Schwartz, B.,King, B.W.,Wisnoski, D.D.,Kang, J.,Eidam, P.M.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L.; Crystal Structures of Human Rip2 Kinase Catalytic Domain Complexed with ATP-Competitive Inhibitors: Foundations for Understanding Inhibitor Selectivity.; Bioorg.Med.Chem., 23:7000-, 2015; PubMed: 26455654; DOI: 10.1016/J.BMC.2015.09.038

実験手法

X-RAY DIFFRACTION (2.79 Å)