5AR7

RIP2 Kinase Catalytic Domain (1 - 310) complex with Biaryl Urea

Summary for 5AR7

• Entry DOI: 10.2210/pdb5ar7/pdb
• Related: 5AR2 5AR3 5AR4 5AR5 5AR8
• Descriptor: RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, 1-(5-TERT-BUTYL-1,2-OXAZOL-3-YL)-3-(4-PYRIDIN-4-YLOXYPHENYL)UREA (3 entities in total)
• Functional Keywords: transferase, kinase domain, kinase inhibitor, structure-based drug design, inhibitor selectivity
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : O43353
• Total number of polymer chains: 2
• Total formula weight: 75916.73

Authors

Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L. (deposition date: 2015-09-24, release date: 2015-10-21, Last modification date: 2024-01-10)

• Primary citation: Charnley, A.K.,Convery, M.A.,Lakdawala Shah, A.,Jones, E.,Hardwicke, P.,Bridges, A.,Ouellette, M.,Totoritis, R.,Schwartz, B.,King, B.W.,Wisnoski, D.D.,Kang, J.,Eidam, P.M.,Votta, B.J.,Gough, P.J.,Marquis, R.W.,Bertin, J.,Casillas, L.; Crystal Structures of Human Rip2 Kinase Catalytic Domain Complexed with ATP-Competitive Inhibitors: Foundations for Understanding Inhibitor Selectivity.; Bioorg.Med.Chem., 23:7000-, 2015; PubMed: 26455654; DOI: 10.1016/J.BMC.2015.09.038

Experimental method

X-RAY DIFFRACTION (2.71 Å)