5AQX

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Summary for 5AQX

• Entry DOI: 10.2210/pdb5aqx/pdb
• Related: 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 5AQW 5AQY 5AQZ 5AR0
• Descriptor: HEAT SHOCK 70 KDA PROTEIN 1A, (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: heat shock protein, hsp70, hsp72, hsc70, atpase, bag1, chaperone, fragment
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 43769.05

Authors

Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L.M. (deposition date: 2015-09-22, release date: 2016-10-05, Last modification date: 2024-01-10)

• Primary citation: Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L.; A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.; Sci Rep, 6:34701-34701, 2016; PubMed: 27708405; DOI: 10.1038/srep34701

Experimental method

X-RAY DIFFRACTION (2.12 Å)