5AQX

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE KC7 A 1390

Chain	Residue
A	THR14
A	GLY339
A	SER340
A	ARG342
A	ASP366
A	HOH2073
A	HOH2082
A	TYR15
A	THR37
A	GLY202
A	GLY230
A	GLU268
A	LYS271
A	ARG272
A	SER275

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1391

Chain	Residue
A	ARG72
A	ARG76
A	TYR149
A	THR226

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS A 1392

Chain	Residue
A	ARG171
A	GLN376

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1393

Chain	Residue
A	ILE28
A	ILE29
A	ALA30

---

Functional Information from PROSITE/UniProt

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS

Chain	Residue	Details
A	ILE9-SER16

---

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL

Chain	Residue	Details
A	ILE197-LEU210

---

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. LvLvGGsTRIPkVqK

Chain	Residue	Details
A	LEU334-LYS348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"27708256","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---