5AQV
Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues
Summary for 5AQV
Entry DOI | 10.2210/pdb5aqv/pdb |
Related | 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQW 5AQX 5AQY 5AQZ 5AR0 |
Descriptor | HEAT SHOCK COGNATE 71 KDA PROTEIN, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, ... (7 entities in total) |
Functional Keywords | heat shock protein, hsp70, hsp72, hsc70, atpase, bag1, chaperone, fragment |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: P11142 Isoform 1: Nucleus. Isoform 2: Cytoplasm. Isoform 4: Cytoplasm: Q99933 |
Total number of polymer chains | 2 |
Total formula weight | 57301.18 |
Authors | Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L.M. (deposition date: 2015-09-22, release date: 2016-10-05, Last modification date: 2024-01-10) |
Primary citation | Jones, A.M.,Westwood, I.M.,Osborne, J.D.,Matthews, T.P.,Cheeseman, M.D.,Rowlands, M.G.,Jeganathan, F.,Burke, R.,Lee, D.,Kadi, N.,Liu, M.,Richards, M.,McAndrew, C.,Yahya, N.,Dobson, S.E.,Jones, K.,Workman, P.,Collins, I.,van Montfort, R.L. A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6:34701-34701, 2016 Cited by PubMed: 27708405DOI: 10.1038/srep34701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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