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5APY

Sequence MATKDDIAN inserted between GCN4 adaptors - Structure T9(9)

Summary for 5APY
Entry DOI10.2210/pdb5apy/pdb
Related5APP 5APQ 5APS 5APT 5APU 5APV 5APW 5APX 5APZ
DescriptorGENERAL CONTROL PROTEIN GCN4 (2 entities in total)
Functional Keywordsdna binding protein, alpha/beta coiled coil, beta layer, trimer
Biological sourceSACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Cellular locationNucleus: P03069
Total number of polymer chains3
Total formula weight34104.25
Authors
Hartmann, M.D.,Mendler, C.T.,Lupas, A.N.,Hernandez Alvarez, B. (deposition date: 2015-09-17, release date: 2016-01-27, Last modification date: 2024-01-10)
Primary citationHartmann, M.D.,Mendler, C.T.,Bassler, J.,Karamichali, I.,Ridderbusch, O.,Lupas, A.N.,Hernandez Alvarez, B.
alpha / beta coiled coils.
Elife, 5:-, 2016
Cited by
PubMed Abstract: Coiled coils are the best-understood protein fold, as their backbone structure can uniquely be described by parametric equations. This level of understanding has allowed their manipulation in unprecedented detail. They do not seem a likely source of surprises, yet we describe here the unexpected formation of a new type of fiber by the simple insertion of two or six residues into the underlying heptad repeat of a parallel, trimeric coiled coil. These insertions strain the supercoil to the breaking point, causing the local formation of short β-strands, which move the path of the chain by 120° around the trimer axis. The result is an α/β coiled coil, which retains only one backbone hydrogen bond per repeat unit from the parent coiled coil. Our results show that a substantially novel backbone structure is possible within the allowed regions of the Ramachandran space with only minor mutations to a known fold.
PubMed: 26771248
DOI: 10.7554/eLife.11861
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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건을2024-11-13부터공개중

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