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5AP2

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Summary for 5AP2
Entry DOI10.2210/pdb5ap2/pdb
Related5AP0 5AP1 5AP3 5AP4 5AP5 5AP6 5AP7
DescriptorDUAL SPECIFICITY PROTEIN KINASE TTK, ISOPROPYL 6-((4-(1,2-DIMETHYL-1H-IMIDAZOL-5-YL)PHENYL)AMINO)-2-(1-METHYL-1H-PYRAZOL-4-YL)-1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLATE (2 entities in total)
Functional Keywordstransferase, mps1, protein kinase, mitosis, drug resistance
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight36584.80
Authors
Primary citationGurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,Mcandrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,Van Montfort, R.L.M.,Linardopoulos, S.
Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.
Cancer Res., 75:3340-, 2015
Cited by
PubMed: 26202014
DOI: 10.1158/0008-5472.CAN-14-3272
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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