5AP0

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Summary for 5AP0

Entry DOI	10.2210/pdb5ap0/pdb
Related	5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7
Descriptor	DUAL SPECIFICITY PROTEIN KINASE TTK, 9-CYCLOPENTYL-2-[[2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY]-PHENYL]AMINO]-7-METHYL-7,9-DIHYDRO-8H-PURIN-8-ONE, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	transferase, mps1, protein kinase, mitosis, drug resistance
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	38337.80
Authors	Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,McAndrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,van Montfort, R.L.M.,Linardopoulos, S. (deposition date: 2015-09-14, release date: 2015-09-23, Last modification date: 2024-01-10)
Primary citation	Gurden, M.D.,Westwood, I.M.,Faisal, A.,Naud, S.,Cheung, K.J.,Mcandrew, C.,Wood, A.,Schmitt, J.,Boxall, K.,Mak, G.,Workman, P.,Burke, R.,Hoelder, S.,Blagg, J.,Van Montfort, R.L.M.,Linardopoulos, S. Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75:3340-, 2015 Cited by PubMed: 26202014 DOI: 10.1158/0008-5472.CAN-14-3272 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation