5AP0

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AU5 A 1795

Chain	Residue
A	ILE531
A	ILE607
A	ASP608
A	SER611
A	LEU654
A	P4C1796
A	DMS1798
A	VAL539
A	ALA551
A	ILE586
A	MET602
A	GLU603
A	CYS604
A	GLY605
A	ASN606

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P4C A 1796

Chain	Residue
A	SER537
A	VAL539
A	LYS553
A	TYR568
A	GLU571
A	MET600
A	MET602
A	ILE663
A	AU51795
A	HOH2012

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE P4C A 1797

Chain	Residue
A	ASN570
A	TRP622
A	LYS625
A	SER626
A	LYS629
A	VAL791
A	GLN792
A	ILE793
A	EDO1806

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 1798

Chain	Residue
A	GLN541
A	CYS604
A	GLY605
A	ASN606
A	AU51795

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1799

Chain	Residue
A	TYR525
A	TYR550
A	VAL601
A	HOH2057

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1800

Chain	Residue
A	ASP595
A	HIS636
A	HIS639
A	ILE782
A	EDO1803
A	HOH2056

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1801

Chain	Residue
A	ASN570
A	TYR574
A	GLN794
A	HOH2058

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1802

Chain	Residue
A	ILE549
A	TYR589
A	CYS604
A	HOH2006

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1803

Chain	Residue
A	THR594
A	ASP595
A	GLN596
A	EDO1800

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1804

Chain	Residue
A	PRO760
A	GLU761
A	LYS762
A	ASP763

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1805

Chain	Residue
A	ARG774
A	ASP775

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1806

Chain	Residue
A	ASP566
A	GLN792
A	P4C1797

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1807

Chain	Residue
A	ASN562
A	ASP566
A	ARG569
A	GLU633
A	EDO1811

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1808

Chain	Residue
A	LEU613
A	LYS617
A	HOH2049

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1809

Chain	Residue
A	ILE738
A	ASN739
A	SER742

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1810

Chain	Residue
A	TYR574
A	HIS641
A	ILE793
A	GLN794

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1811

Chain	Residue
A	HIS636
A	THR637
A	GLN640
A	EDO1807
A	HOH2016

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1812

Chain	Residue
A	TRP622
A	GLU623
A	SER626
A	GLY658

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGGSSKVFqVlnekkqi...........YAIK

Chain	Residue	Details
A	ILE531-LYS553

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHsDLKpaNFLI

Chain	Residue	Details
A	ILE643-ILE655

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP647

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE531
A	LYS553

---