5AOL
Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine
Summary for 5AOL
Entry DOI | 10.2210/pdb5aol/pdb |
Related | 5AOI 5AOJ 5AOK 5AOM |
Descriptor | CELLULAR TUMOR ANTIGEN P53, 3-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, ZINC ION, ... (4 entities in total) |
Functional Keywords | cell cycle, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 49447.48 |
Authors | Joerger, A.C.,Harbrecht, H. (deposition date: 2015-09-10, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Joerger, A.C.,Bauer, M.R.,Wilcken, R.,Baud, M.G.J.,Harbrecht, H.,Exner, T.E.,Boeckler, F.M.,Spencer, J.,Fersht, A.R. Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23:2246-, 2015 Cited by PubMed: 26636255DOI: 10.1016/J.STR.2015.10.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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