5AO4

Crystal structure of in vitro phosphorylated human SAMHD1 (amino acid residues 115-626) bound to GTP

Summary for 5AO4

Entry DOI	10.2210/pdb5ao4/pdb
Related	5AO0 5AO1 5AO2 5AO3
Descriptor	DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, FE (III) ION, GUANOSINE-5'-TRIPHOSPHATE (3 entities in total)
Functional Keywords	hydrolase, deoxynucleoside triphosphate triphosphohydrolase, hiv restriction factor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9Y3Z3
Total number of polymer chains	4
Total formula weight	251412.66
Authors	Arnold, L.H.,Schwefel, D.,Taylor, I.A. (deposition date: 2015-09-09, release date: 2015-10-14, Last modification date: 2024-01-10)
Primary citation	Arnold, L.H.,Groom, H.C.T.,Kunzelmann, S.,Schwefel, D.,Caswell, S.J.,Ordonez, P.,Mann, M.C.,Rueschenbaum, S.,Goldstone, D.C.,Pennell, S.,Howell, S.A.,Stoye, J.P.,Webb, M.,Taylor, I.A.,Bishop, K.N. Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction. Plos Pathog., 11:5194-, 2015 Cited by PubMed: 26431200 DOI: 10.1371/JOURNAL.PPAT.1005194 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation