5AO3
Crystal structure of human SAMHD1 (amino acid residues 115-626) bound to GTP
Summary for 5AO3
Entry DOI | 10.2210/pdb5ao3/pdb |
Related | 5AO0 5AO1 5AO2 5AO4 |
Descriptor | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, FE (III) ION, GUANOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | hydrolase, deoxynucleoside triphosphate triphosphohydrolase, hiv restriction factor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q9Y3Z3 |
Total number of polymer chains | 4 |
Total formula weight | 252469.36 |
Authors | Schwefel, D.,Taylor, I.A. (deposition date: 2015-09-09, release date: 2016-04-20, Last modification date: 2024-01-10) |
Primary citation | Arnold, L.H.,Groom, H.C.T.,Kunzelmann, S.,Schwefel, D.,Caswell, S.J.,Ordonez, P.,Mann, M.C.,Rueschenbaum, S.,Goldstone, D.C.,Pennell, S.,Howell, S.A.,Stoye, J.P.,Webb, M.,Taylor, I.A.,Bishop, K.N. Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction. Plos Pathog., 11:5194-, 2015 Cited by PubMed: 26431200DOI: 10.1371/JOURNAL.PPAT.1005194 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.004 Å) |
Structure validation
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