5AO3
Crystal structure of human SAMHD1 (amino acid residues 115-626) bound to GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 | polymer | 538 | 62274.1 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | HOMO SAPIENS (HUMAN) | DNTPASE, DENDRITIC CELL-DERIVED IFNG-INDUCED PROTEIN, DCIP, MONOCYTE PROTEIN 5, MOP-5, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN 1, SAMHD1 |
| 2 | E, J, O, S (A, B, C, D) | FE (III) ION | non-polymer | 55.8 | 4 | Chemie (FE) PubChem (29936) | |||
| 3 | F, P, T, U (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | G, H, I, K, L... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 5 | X, Y, Z (A, B, C) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 115 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 89 | - | expression tag |
| Ala 90 | - | expression tag |
| Ser 91 | - | expression tag |
| Trp 92 | - | expression tag |
| Ser 93 | - | expression tag |
| His 94 | - | expression tag |
| Pro 95 | - | expression tag |
| Gln 96 | - | expression tag |
| Phe 97 | - | expression tag |
| Glu 98 | - | expression tag |
| Lys 99 | - | expression tag |
| Gly 100 | - | expression tag |
| Ala 101 | - | expression tag |
| Leu 102 | - | expression tag |
| Glu 103 | - | expression tag |
| Val 104 | - | expression tag |
| Leu 105 | - | expression tag |
| Phe 106 | - | expression tag |
| Gln 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Pro 109 | - | expression tag |
| Gly 110 | - | expression tag |
| Tyr 111 | - | expression tag |
| Gln 112 | - | expression tag |
| Asp 113 | - | expression tag |
| Pro 114 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 249096.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 3372.8 | |
| All* | Total formula weight | 252469.4 |
