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5AM6

Native FGFR1 with an inhibitor

Replaces:  4UWZ
Summary for 5AM6
Entry DOI10.2210/pdb5am6/pdb
Related5AM7
DescriptorFIBROBLAST GROWTH FACTOR RECEPTOR 1, CHLORIDE ION, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, ... (4 entities in total)
Functional Keywordstransferase, fgfr, growth factor, cancer, dovitinib, tki258, kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains2
Total formula weight71508.44
Authors
Bunney, T.D.,Wan, S.,Thiyagarajan, N.,Sutto, L.,Williams, S.V.,Ashford, P.,Koss, H.,Knowles, M.A.,Gervasio, F.L.,Coveney, P.V.,Katan, M. (deposition date: 2015-03-10, release date: 2015-03-18, Last modification date: 2024-01-10)
Primary citationBunney, T.,Wan, S.,Thiyagarajan, N.,Sutto, L.,Williams, S.V.,Ashford, P.,Koss, H.,Knowles, M.A.,Gervasio, F.L.,Coveney, P.V.,Katan, M.
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
Ebiomedicine, 2:194-, 2015
Cited by
PubMed: 26097890
DOI: 10.1016/J.EBIOM.2015.02.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.96 Å)
Structure validation

217705

건을2024-03-27부터공개중

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