5AKT

Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-4'-O- glucuronide

Summary for 5AKT

Related5AKS 5AKV 5AL0 5AL8
DescriptorTRANSTHYRETIN, SULFATE ION, Resveratrol-4'-O-glucuronide, ... (4 entities in total)
Functional Keywordstransport protein, amyloid, fibrillogenesis, fibrillogenesis inhibitors, polyphenols, polyphenol metabolites, negative cooperativity
Biological sourceHomo sapiens (HUMAN)
Total number of polymer chains2
Total molecular weight28555.58
Authors
Florio, P.,Folli, C.,Cianci, M.,Del Rio, D.,Zanotti, G.,Berni, R. (deposition date: 2015-03-05, release date: 2015-10-21, Last modification date: 2019-05-15)
Primary citation
Florio, P.,Folli, C.,Cianci, M.,Del Rio, D.,Zanotti, G.,Berni, R.
Transthyretin Binding Heterogeneity and Anti-Amyloidogenic Activity of Natural Polyphenols and Their Metabolites
J.Biol.Chem., 290:29769-, 2015
PubMed: 26468275 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M115.690172
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2039 0.9% 0.5% 3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5akt.pdb1.gz [101.27 KB])