5AJO

Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-3,13

Summary for 5AJO

• Entry DOI: 10.2210/pdb5ajo/pdb
• Related: 5AJN 5AJP
• Descriptor: POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, MUCIN, 2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (5 entities in total)
• Functional Keywords: transferase, afm, saxs, lectin domain, coarse-grained model, glycopeptides, inactive form, active form, compact form, extended form
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 69791.70

Authors

Lira-Navarrete, E.,delasRivas, M.,Companon, I.,Pallares, M.C.,Kong, Y.,Iglesias-Fernandez, J.,Bernardes, G.J.L.,Peregrina, J.M.,Rovira, C.,Bernado, P.,Bruscolini, P.,Clausen, H.,Lostao, A.,Corzana, F.,Hurtado-Guerrero, R. (deposition date: 2015-02-26, release date: 2015-03-11, Last modification date: 2024-01-10)

• Primary citation: Lira-Navarrete, E.,De Las Rivas, M.,Companon, I.,Pallares, M.C.,Kong, Y.,Iglesias-Fernandez, J.,Bernardes, G.J.L.,Peregrina, J.M.,Rovira, C.,Bernado, P.,Bruscolini, P.,Clausen, H.,Lostao, A.,Corzana, F.,Hurtado-Guerrero, R.; Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.; Nat.Commun., 6:6937-, 2015; PubMed: 25939779; DOI: 10.1038/NCOMMS7937

Experimental method

X-RAY DIFFRACTION (1.48 Å)