5AJ1
Solution Structure of the Smarc Domain
Summary for 5AJ1
| Entry DOI | 10.2210/pdb5aj1/pdb |
| NMR Information | BMRB: 26553 |
| Descriptor | SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 (1 entity in total) |
| Functional Keywords | structural protein |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Nucleus: Q12824 |
| Total number of polymer chains | 1 |
| Total formula weight | 12995.91 |
| Authors | Allen, M.D.,Freund, S.M.V.,Zinzalla, G.,Bycroft, M. (deposition date: 2015-02-19, release date: 2015-08-05, Last modification date: 2024-06-19) |
| Primary citation | Allen, M.D.,Freund, S.M.V.,Zinzalla, G.,Bycroft, M. The Swi/Snf Subunit Ini1 Contains an N-Terminal Winged Helix DNA Binding Domain that is a Target for Mutations in Schwannomatosis. Structure, 23:1344-, 2015 Cited by PubMed Abstract: SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit is mutated in both malignant rhabdoid tumor, a highly aggressive childhood cancer, and schwannomatosis, a tumor-predisposing syndrome characterized by mostly benign tumors of the CNS. Here, we show that mutations in INI1 that cause schwannomatosis target a hitherto unidentified N-terminal winged helix DNA binding domain that is also present in the BAF45a/PHF10 subunit of the SWI/SNF complex. The domain is structurally related to the SKI/SNO/DAC domain, which is found in a number of metazoan chromatin-associated proteins. PubMed: 26073604DOI: 10.1016/J.STR.2015.04.021 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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