5AHJ
Yeast 20S proteasome in complex with Macyranone A
Summary for 5AHJ
Entry DOI | 10.2210/pdb5ahj/pdb |
Descriptor | PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT BETA TYPE-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (19 entities in total) |
Functional Keywords | hydrolase, proteasome, natural product, target identification, inhibition, binding analysis |
Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 732906.57 |
Authors | Etzbach, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Mueller, R. (deposition date: 2015-02-06, release date: 2015-02-18, Last modification date: 2024-01-10) |
Primary citation | Keller, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Muller, R. Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome. J.Am.Chem.Soc., 137:8121-, 2015 Cited by PubMed: 26050527DOI: 10.1021/JACS.5B03833 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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