5AHJ

Yeast 20S proteasome in complex with Macyranone A

5AHJ の概要

• エントリーDOI: 10.2210/pdb5ahj/pdb
• 分子名称: PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT BETA TYPE-4, PROTEASOME SUBUNIT BETA TYPE-5, ... (19 entities in total)
• 機能のキーワード: hydrolase, proteasome, natural product, target identification, inhibition, binding analysis
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 732906.57

構造登録者

Etzbach, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Mueller, R. (登録日: 2015-02-06, 公開日: 2015-02-18, 最終更新日: 2024-01-10)

• 主引用文献: Keller, L.,Plaza, A.,Dubiella, C.,Groll, M.,Kaiser, M.,Muller, R.; Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome.; J.Am.Chem.Soc., 137:8121-, 2015; PubMed: 26050527; DOI: 10.1021/JACS.5B03833

実験手法

X-RAY DIFFRACTION (2.8 Å)