5AGS

Crystal structure of the LeuRS editing domain of Mycobacterium tuberculosis in complex with the adduct 3-(Aminomethyl)-4-bromo-7-ethoxybenzo[c][1,2]oxaborol-1(3H)-ol-AMP

5AGS の概要

• エントリーDOI: 10.2210/pdb5ags/pdb
• 関連するPDBエントリー: 5AGR 5AGT
• 分子名称: LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE, ... (4 entities in total)
• 機能のキーワード: ligase, m.tuberculosis, leucine-trna ligase activity, atp + l-leucine + trna(leu) gives amp + diphosphate + l-leucyl- trna(leu) aminoacyl-trna editing activity, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• 細胞内の位置: Cytoplasm : P9WFV1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25655.10

構造登録者

Palencia, A.,Li, X.,Alley, M.R.K.,Ding, C.,Easom, E.E.,Hernandez, V.,Meewan, M.,Mohan, M.,Rock, F.L.,Franzblau, S.G.,Wang, Y.,Lenaerts, A.J.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J. (登録日: 2015-02-03, 公開日: 2016-03-09, 最終更新日: 2024-01-10)

• 主引用文献: Palencia, A.,Li, X.,Bu, W.,Choi, W.,Ding, C.Z.,Easom, E.E.,Feng, L.,Hernandez, V.,Houston, P.,Liu, L.,Meewan, M.,Mohan, M.,Rock, F.L.,Sexton, H.,Zhang, S.,Zhou, Y.,Wan, B.,Wang, Y.,Franzblau, S.G.,Woolhiser, L.,Gruppo, V.,Lenaerts, A.J.,O'Malley, T.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Ioerger, T.R.,Sacchettini, J.C.,Rullas, J.,Angulo-Barturen, I.,Perez-Herran, E.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J.,Alley, M.R.K.; Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.; Antimicrob.Agents Chemother., 60:6271-, 2016; PubMed: 27503647; DOI: 10.1128/AAC.01339-16

実験手法

X-RAY DIFFRACTION (1.47 Å)