5AGR の概要
| 関連するPDBエントリー | 5AGS 5AGT |
|---|---|
| 分子名称 | LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ... (6 entities in total) |
| 機能のキーワード | ligase, atp + l-leucine + trna(leu) gives amp + diphosphate + l-leucyl- trna(leu) aminoacyl-trna editing activity, aminoacyl-trna synthetase, protein biosynthesis, novel boron inhibitors of leurs |
| 由来する生物種 | MYCOBACTERIUM TUBERCULOSIS |
| ポリマー鎖数 | 1 |
| 分子量合計 | 25766.42 |
| 構造登録者 | Palencia, A.,Li, X.,Alley, M.R.K.,Ding, C.,Easom, E.E.,Hernandez, V.,Meewan, M.,Mohan, M.,Rock, F.L.,Franzblau, S.G.,Wang, Y.,Lenaerts, A.J.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J. (登録日: 2015-02-03, 公開日: 2016-03-02, 最終更新日: 2018-06-20) |
| 主引用文献 | Palencia, A.,Li, X.,Bu, W.,Choi, W.,Ding, C.Z.,Easom, E.E.,Feng, L.,Hernandez, V.,Houston, P.,Liu, L.,Meewan, M.,Mohan, M.,Rock, F.L.,Sexton, H.,Zhang, S.,Zhou, Y.,Wan, B.,Wang, Y.,Franzblau, S.G.,Woolhiser, L.,Gruppo, V.,Lenaerts, A.J.,O'Malley, T.,Parish, T.,Cooper, C.B.,Waters, M.G.,Ma, Z.,Ioerger, T.R.,Sacchettini, J.C.,Rullas, J.,Angulo-Barturen, I.,Perez-Herran, E.,Mendoza, A.,Barros, D.,Cusack, S.,Plattner, J.J.,Alley, M.R.K. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60:6271-, 2016 PubMed: 27503647 (主引用文献が同じPDBエントリー) DOI: 10.1128/AAC.01339-16  Import into Mendeley |
| 実験手法 | X-RAY DIFFRACTION (1.3 Å) |
