5AGE

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINONE LIGAND

5AGE の概要

• エントリーDOI: 10.2210/pdb5age/pdb
• 関連するPDBエントリー: 5AG4 5AG5 5AG6 5AG7
• 分子名称: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 4-[(5-methyl-1,2-oxazol-3-yl)methyl]-7-[4-(1-methylpiperidin-4-yl)butyl]-2H-1,4-benzoxazin-3(4H)-one, TETRADECANOYL-COA, ... (4 entities in total)
• 機能のキーワード: nmt, acyltransferase, transferase, drug discovery
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51888.65

構造登録者

Robinson, D.A.,Spinks, D.,Smith, V.C.,Thompson, S.,Smith, A.,Torrie, L.S.,McElroy, S.P.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (登録日: 2015-01-29, 公開日: 2015-10-07, 最終更新日: 2024-01-10)

• 主引用文献: Spinks, D.,Smith, V.,Thompson, S.,Robinson, D.A.,Luksch, T.,Smith, A.,Torrie, L.S.,Mcelroy, S.,Stojanovski, L.,Norval, S.,Collie, I.T.,Hallyburton, I.,Rao, B.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.; Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.; Chemmedchem, 10:1821-, 2015; PubMed: 26395087; DOI: 10.1002/CMDC.201500301

実験手法

X-RAY DIFFRACTION (2 Å)