5AFZ

Thrombin in complex with (2R)-2-(benzylsulfonylamino)-N-(2-((4- carbamimidoylphenyl)methylamino)-2-oxo-propyl)-3-phenyl-propanamide

5AFZ の概要

• エントリーDOI: 10.2210/pdb5afz/pdb
• 関連するPDBエントリー: 5AF9 5AFY
• 分子名称: Prothrombin, Hirudin-2, SODIUM ION, ... (8 entities in total)
• 機能のキーワード: hydrolase, hydrolase inhibitor complex, serine protease, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, fragment, glycosylation, blood
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35502.28

構造登録者

Ruehmann, E.,Heine, A.,Klebe, G. (登録日: 2015-01-27, 公開日: 2015-08-26, 最終更新日: 2024-01-31)

• 主引用文献: Ruehmann, E.,Betz, M.,Heine, A.,Klebe, G.; Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.; J.Med.Chem., 58:6960-, 2015; PubMed: 26270568; DOI: 10.1021/ACS.JMEDCHEM.5B00812

実験手法

X-RAY DIFFRACTION (1.53 Å)