5AFK
alpha7-AChBP in complex with lobeline and fragment 2
Summary for 5AFK
Entry DOI | 10.2210/pdb5afk/pdb |
Related | 5AFH 5AFJ 5AFL 5AFM 5AFN |
Descriptor | ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | transport protein, pentameric ligand-gated ion channels, cys-loop receptor, nicotinic acetylcholine receptor, allosteric modulation, drug discovery |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 5 |
Total formula weight | 124440.57 |
Authors | Spurny, R.,Debaveye, S.,Farinha, A.,Veys, K.,Gossas, T.,Atack, J.,Bertrand, D.,Kemp, J.,Vos, A.,Danielson, U.H.,Tresadern, G.,Ulens, C. (deposition date: 2015-01-22, release date: 2015-05-06, Last modification date: 2020-07-29) |
Primary citation | Spurny, R.,Debaveye, S.,Farinha, A.,Veys, K.,Vos, A.M.,Gossas, T.,Atack, J.,Bertrand, S.,Bertrand, D.,Danielson, U.H.,Tresadern, G.,Ulens, C. Molecular Blueprint of Allosteric Binding Sites in a Homologue of the Agonist-Binding Domain of the Alpha7 Nicotinic Acetylcholine Receptor. Proc.Natl.Acad.Sci.USA, 112:E2543-, 2015 Cited by PubMed: 25918415DOI: 10.1073/PNAS.1418289112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.381 Å) |
Structure validation
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