5AE8

Crystal structure of mouse PI3 kinase delta in complex with GSK2269557

5AE8 の概要

• エントリーDOI: 10.2210/pdb5ae8/pdb
• 関連するPDBエントリー: 5AE9
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole (3 entities in total)
• 機能のキーワード: transferase, pi3 kinase delta
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 108264.20

構造登録者

Down, K.D.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, N. (登録日: 2015-08-26, 公開日: 2015-09-16, 最終更新日: 2024-06-19)

• 主引用文献: Down, K.,Amour, A.,Baldwin, I.R.,Cooper, A.W.J.,Deakin, A.M.,Felton, L.M.,Guntrip, S.B.,Hardy, C.,Harrison, Z.A.,Jones, K.L.,Jones, P.,Keeling, S.E.,Le, J.,Livia, S.,Lucas, F.,Lunniss, C.J.,Parr, N.J.,Robinson, E.,Rowland, P.,Smith, S.,Thomas, D.A.,Vitulli, G.,Washio, Y.,Hamblin, J.N.; Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase Gamma for the Treatment of Respiratory Disease.; J.Med.Chem., 58:7381-, 2015; PubMed: 26301626; DOI: 10.1021/ACS.JMEDCHEM.5B00767

実験手法

X-RAY DIFFRACTION (2.42 Å)