5AE1

Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460

Summary for 5AE1

Entry DOI	10.2210/pdb5ae1/pdb
Related	5ADZ 5AE2 5AE3
Descriptor	ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL, (3-(2-FLUOROPHENYL)-N-(1-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)ETHYL)BUTANAMIDE), FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	transferase, ether phospholipid, cancer, flavin
Biological source	CAVIA PORCELLUS (DOMESTIC GUINEA PIG)
Cellular location	Peroxisome: P97275
Total number of polymer chains	4
Total formula weight	296646.75
Authors	Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A. (deposition date: 2015-08-25, release date: 2015-09-09, Last modification date: 2024-01-10)
Primary citation	Piano, V.,Benjamin, D.I.,Valente, S.,Nenci, S.,Marrocco, B.,Mai, A.,Aliverti, A.,Nomura, D.K.,Mattevi, A. Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents. Acs Chem.Biol., 10:2589-, 2015 Cited by PubMed: 26322624 DOI: 10.1021/ACSCHEMBIO.5B00466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation