Summary for 5ADX
| Entry DOI | 10.2210/pdb5adx/pdb |
| EMDB information | 2856 2857 |
| Descriptor | ACTIN RELATED PROTEIN 1, DYNACTIN 5, DYNACTIN SUBUNIT 6, ... (17 entities in total) |
| Functional Keywords | structural protein, dynein co-factor, actin-like filament, cellular cargo transport |
| Biological source | SUS SCROFA (PIG) More |
| Cellular location | Cytoplasm, cytoskeleton: Q6QAQ1 |
| Total number of polymer chains | 27 |
| Total formula weight | 805390.81 |
| Authors | Zhang, K.,Urnavicius, L.,Diamant, A.G.,Motz, C.,Schlage, M.A.,Yu, M.,Patel, N.A.,Robinson, C.V.,Carter, A.P. (deposition date: 2015-08-24, release date: 2015-12-30, Last modification date: 2024-05-08) |
| Primary citation | Urnavicius, L.,Zhang, K.,Diamant, A.G.,Motz, C.,Schlager, M.A.,Yu, M.,Patel, N.A.,Robinson, C.V.,Carter, A.P. The Structure of the Dynactin Complex and its Interaction with Dynein. Science, 347:1441-, 2015 Cited by PubMed Abstract: Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 angstroms. Our reconstruction reveals how dynactin is built around a filament containing eight copies of the actin-related protein Arp1 and one of β-actin. The filament is capped at each end by distinct protein complexes, and its length is defined by elongated peptides that emerge from the α-helical shoulder domain. A further 8.2 angstrom structure of the complex between dynein, dynactin, and the motility-inducing cargo adaptor Bicaudal-D2 shows how the translational symmetry of the dynein tail matches that of the dynactin filament. The Bicaudal-D2 coiled coil runs between dynein and dynactin to stabilize the mutually dependent interactions between all three components. PubMed: 25814576DOI: 10.1126/SCIENCE.AAA4080 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
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