5ADO

Crystal structure of the paraoxon-modified A.17 antibody FAB fragment - Light chain S35R mutant

Summary for 5ADO

Entry DOI	10.2210/pdb5ado/pdb
Related	5ADP
Descriptor	FAB A.17, DIETHYL PHOSPHONATE, ... (4 entities in total)
Functional Keywords	immune system, enzyme reprogramming, antibodies, ig superfamily, in silico antibody maturation
Biological source	Homo sapiens (HUMAN) More
Total number of polymer chains	2
Total formula weight	54215.72
Authors	Chatziefthimiou, S.D.,Smirnov, I.V.,Golovin, A.V.,Stepanova, A.V.,Peng, Y.,Zolotareva, O.I.,Belogurov, A.A.,Ponomarenko, N.A.,Blackburn, G.M.,Gabibov, A.A.,Lerner, R.,Wilmanns, M. (deposition date: 2015-08-21, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citation	Smirnov, I.V.,Golovin, A.V.,Chatziefthimiou, S.D.,Stepanova, A.V.,Peng, Y.,Zolotareva, O.I.,Belogurov, A.A.,Kurkova, I.N.,Ponomarenko, N.A.,Wilmanns, M.,Blackburn, G.M.,Gabibov, A.G.,Lerner, R.A. Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites. Sci.Adv., 2:01695-, 2016 Cited by PubMed: 27774510 DOI: 10.1126/SCIADV.1501695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation