5ADC

Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(((5-((Methylamino)methyl)pyridin-3-yl)oxy)methyl) quinolin-2-amine

5ADC の概要

• エントリーDOI: 10.2210/pdb5adc/pdb
• 関連するPDBエントリー: 5AD4 5AD5 5AD6 5AD7 5AD8 5AD9 5ADA 5ADB 5ADD 5ADE 5ADF 5ADG 5ADI 5ADJ 5ADK 5ADL 5ADM 5ADN
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100108.69

構造登録者

Li, H.,Poulos, T.L. (登録日: 2015-08-20, 公開日: 2015-10-28, 最終更新日: 2015-11-25)

• 主引用文献: Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.; J.Med.Chem., 58:8694-, 2015; PubMed: 26469213; DOI: 10.1021/ACS.JMEDCHEM.5B01330

実験手法

X-RAY DIFFRACTION (2.1 Å)