5AD8
Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-((3-Aminomethyl)phenoxy)methyl)quinolin-2-amine
Summary for 5AD8
Entry DOI | 10.2210/pdb5ad8/pdb |
Related | 5AD4 5AD5 5AD6 5AD7 5AD9 5ADA 5ADB 5ADC 5ADD 5ADE 5ADF 5ADG 5ADI 5ADJ 5ADK 5ADL 5ADM 5ADN |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100082.69 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2015-08-20, release date: 2015-10-28, Last modification date: 2024-05-08) |
Primary citation | Cinelli, M.A.,Li, H.,Pensa, A.V.,Kang, S.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58:8694-, 2015 Cited by PubMed: 26469213DOI: 10.1021/ACS.JMEDCHEM.5B01330 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.905 Å) |
Structure validation
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