5ACY

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1-(2R,4S)-2-methyl-4-(phenylamino)-6-4-(piperidin-1-ylmethyl)phenyl-1,2,3,4- tetrahydroquinolin-1-yl-ethan-1-one

5ACY の概要

• エントリーDOI: 10.2210/pdb5acy/pdb
• 分子名称: BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, 1-[(2S,4R)-2-methyl-4-(phenylamino)-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydroquinolin-1(2H)-yl]ethanone, ... (4 entities in total)
• 機能のキーワード: transcription, inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31292.20

構造登録者

Chung, C. (登録日: 2015-08-18, 公開日: 2015-10-07, 最終更新日: 2024-05-08)

• 主引用文献: Sullivan, J.M.,Badimon, A.,Schaefer, U.,Ayata, P.,Gray, J.,Chung, C.,Von Schimmelmann, M.,Zhang, F.,Garton, N.,Smithers, N.,Lewis, H.,Tarakhovsky, A.,Prinjha, R.K.,Schaefer, A.; Autism-Like Syndrome is Induced by Pharmacological Suppression of Bet Proteins in Young Mice.; J.Exp.Med., 212:1771-, 2015; PubMed: 26392221; DOI: 10.1084/JEM.20151271

実験手法

X-RAY DIFFRACTION (2.01 Å)