5AC2
human aldehyde dehydrogenase 1A1 with duocarmycin analog
Summary for 5AC2
Entry DOI | 10.2210/pdb5ac2/pdb |
Related | 5ABM 5AC0 5AC1 |
Descriptor | RETINAL DEHYDROGENASE 1, 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, YTTERBIUM (III) ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase, oxidation-reduction process, aldehyde dehydrogenase activity |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P00352 |
Total number of polymer chains | 1 |
Total formula weight | 56408.59 |
Authors | Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A. (deposition date: 2015-08-11, release date: 2015-08-26, Last modification date: 2024-01-10) |
Primary citation | Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew.Chem.Int.Ed.Engl., 54:13550-, 2015 Cited by PubMed: 26373694DOI: 10.1002/ANIE.201505749 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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