5AAN
Crystal structure of Drosophila NCS-1 bound to penothiazine FD44
Summary for 5AAN
Entry DOI | 10.2210/pdb5aan/pdb |
Descriptor | CG5907-PA, ISOFORM A, CALCIUM ION, N-phenothiazin-10-yl-2-piperidin-1-yl-ethanamide, ... (5 entities in total) |
Functional Keywords | calcium sensor, calcium-binding protein |
Biological source | DROSOPHILA MELANOGASTER (FRUIT FLY) |
Total number of polymer chains | 1 |
Total formula weight | 22502.28 |
Authors | Chaves-Sanjuan, A.,Infantes, L.,Sanchez-Barrena, M.J. (deposition date: 2015-07-27, release date: 2017-01-25, Last modification date: 2024-01-10) |
Primary citation | Mansilla, A.,Chaves-Sanjuan, A.,Campillo, N.E.,Semelidou, O.,Martinez-Gonzalez, L.,Infantes, L.,Gonzalez-Rubio, J.M.,Gil, C.,Conde, S.,Skoulakis, E.M.,Ferrus, A.,Martinez, A.,Sanchez-Barrena, M.J. Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc. Natl. Acad. Sci. U.S.A., 114:E999-E1008, 2017 Cited by PubMed: 28119500DOI: 10.1073/pnas.1611089114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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