5AAM

Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency

Replaces:  4UD3

Summary for 5AAM

• Entry DOI: 10.2210/pdb5aam/pdb
• Descriptor: SCFV513, ENVELOPE PROTEIN (3 entities in total)
• Functional Keywords: immune system, scfv dengue antibody envelope domain iii
• Biological source: MUS MUSCULUS (HOUSE MOUSE); More
• Total number of polymer chains: 4
• Total formula weight: 79983.83

Authors

Wong, Y.H.,Robinson, L.N.,Lescar, J.,Sasisekharan, R. (deposition date: 2015-07-27, release date: 2015-08-05, Last modification date: 2024-01-10)

• Primary citation: Robinson, L.N.,Tharakaraman, K.,Rowley, K.J.,Costa, V.V.,Chan, K.R.,Wong, Y.H.,Ong, L.C.,Tan, H.C.,Koch, T.,Cain, D.,Kirloskar, R.,Viswanathan, K.,Liew, C.W.,Tissire, H.,Ramakrishnan, B.,Myette, J.R.,Babcock, G.J.,Sasisekharan, V.,Alonso, S.,Chen, J.,Lescar, J.,Shriver, Z.,Ooi, E.E.,Sasisekharan, R.; Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.; Cell(Cambridge,Mass.), 162:493-, 2015; PubMed: 26189681; DOI: 10.1016/J.CELL.2015.06.057

Experimental method

X-RAY DIFFRACTION (2.49 Å)